Assay Detail
Functional
CHEMBL652376
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Inhibition of Bradykinin receptor B2-mediated contractions of rat uterus smooth muscle
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Uterus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nonpeptide bradykinin B2 receptor antagonists: conversion of rodent-selective bradyzide analogues into potent, orally-active human bradykinin B2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.67 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112220 | — | — | 1 | 8.72 |
| CHEMBL2112283 | — | — | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112220 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2112283 | — | IC50 | = | 2.4 | nM | 8.62 |