Assay Detail
Binding
CHEMBL652388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of [3H]dihydroalprenolol radioligand binding to Beta-2 adrenergic receptor in calf lung membranes.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Lung |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.55 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266195 | ALPRENOLOL | 2.0 | 1 | 8.53 |
| CHEMBL26917 | — | — | 1 | 7.75 |
| CHEMBL1788270 | — | — | 1 | 7.70 |
| CHEMBL368457 | — | — | 1 | 7.61 |
| CHEMBL305153 | — | — | 1 | 7.51 |
| CHEMBL423 | BETAXOLOL | 4.0 | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266195 | ALPRENOLOL | IC50 | = | 2.98 | nM | 8.53 |
| CHEMBL26917 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL1788270 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL368457 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL305153 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL423 | BETAXOLOL | IC50 | = | 657.0 | nM | 6.18 |