Assay Detail
Binding
CHEMBL652421
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Ability to bind to human Beta-2 adrenergic receptor using membranes of stably transfected CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carboxyl-promoted enhancement of selectivity for the 3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-3 binding selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.83 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38486 | — | — | 1 | 8.49 |
| CHEMBL39596 | — | — | 1 | 6.95 |
| CHEMBL38569 | — | — | 1 | 6.77 |
| CHEMBL41113 | — | — | 1 | 6.58 |
| CHEMBL284782 | — | — | 1 | 6.20 |
| CHEMBL38538 | — | — | 1 | 5.65 |
| CHEMBL290752 | — | — | 1 | 4.77 |
| CHEMBL41948 | — | — | 1 | 4.40 |
| CHEMBL40966 | — | — | 1 | 4.37 |
| CHEMBL39334 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38486 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL39596 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL38569 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL41113 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL284782 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL38538 | — | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL290752 | — | Ki | = | 17100.0 | nM | 4.77 |
| CHEMBL41948 | — | Ki | = | 39700.0 | nM | 4.40 |
| CHEMBL40966 | — | Ki | = | 42600.0 | nM | 4.37 |
| CHEMBL39334 | — | Ki | = | 73700.0 | nM | 4.13 |