Assay Detail
Binding
CHEMBL652443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement [3H]-PK 11195 from rat adrenal peripheral-type benzodiazepine receptor (PBR)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.70 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325169 | — | — | 1 | 9.00 |
| CHEMBL117444 | — | — | 1 | 8.96 |
| CHEMBL325649 | — | — | 1 | 8.72 |
| CHEMBL325025 | — | — | 1 | 8.72 |
| CHEMBL117589 | — | — | 1 | 8.60 |
| CHEMBL326772 | — | — | 1 | 8.55 |
| CHEMBL115470 | — | — | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325169 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL117444 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL325649 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL325025 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL117589 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL326772 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL115470 | — | Ki | = | 4.8 | nM | 8.32 |