Assay Detail
Binding
CHEMBL652444
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Displacement of [3H]-Ro- 5-4864 from rat adrenal peripheral-type benzodiazepine receptor (PBR)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.75 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325169 | — | — | 1 | 9.10 |
| CHEMBL117444 | — | — | 1 | 8.89 |
| CHEMBL326772 | — | — | 1 | 8.77 |
| CHEMBL325649 | — | — | 1 | 8.74 |
| CHEMBL325025 | — | — | 1 | 8.72 |
| CHEMBL117589 | — | — | 1 | 8.59 |
| CHEMBL115470 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325169 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL117444 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL326772 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL325649 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL325025 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL117589 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL115470 | — | Ki | = | 3.6 | nM | 8.44 |