Assay Detail
Binding
CHEMBL652458
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Compound was evaluated for beta-lactamase inhibition activity of Enterobacter cloacae after 15 min of pre-incubation with the enzyme at 37 degree C
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of novel penem sulfoxides and sulfones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.36 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67925 | — | — | 1 | 8.40 |
| CHEMBL69141 | — | — | 1 | 6.52 |
| CHEMBL419441 | — | — | 1 | 6.52 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67925 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL69141 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL419441 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 100000.0 | nM | 4.00 |