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Assay Detail

CHEMBL652466

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effect of compound against Moloney murine sarcoma virus (MSV)-induced transformation of C3H/3T3 embryo murine fibroblasts
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type C3H/3T3
Confidence 1 — Organism
Curated By Expert

Target

C3H/3T3 (CHEMBL614372)
Type CELL-LINE
Organism Mus musculus

Publication

cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system.
Meier C, Knispel T, De Clercq E, Balzarini J.
J Med Chem (1999) 42 : 1604 -1614
PubMed 10229629 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 5.44 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL289329 1 6.52
CHEMBL41402 1 5.94
CHEMBL42698 1 5.94
CHEMBL41053 3 5.92
CHEMBL40598 1 5.91
CHEMBL991 STAVUDINE 4.0 1 4.82
CHEMBL290427 1 4.46
CHEMBL23094 1 4.40
CHEMBL288769 1 -
CHEMBL295820 1 -
CHEMBL129 ZIDOVUDINE 4.0 1 -
CHEMBL290935 1 -
CHEMBL42533 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL289329 EC50 = 300.0 nM 6.52
CHEMBL41402 EC50 = 1140.0 nM 5.94
CHEMBL42698 EC50 = 1140.0 nM 5.94
CHEMBL41053 EC50 = 1210.0 nM 5.92
CHEMBL40598 EC50 = 1240.0 nM 5.91
CHEMBL41053 EC50 = 2830.0 nM 5.55
CHEMBL41053 EC50 = 12800.0 nM 4.89
CHEMBL991 STAVUDINE EC50 = 15000.0 nM 4.82
CHEMBL290427 EC50 = 35000.0 nM 4.46
CHEMBL23094 EC50 = 40000.0 nM 4.40
CHEMBL288769 EC50 > 50000.0 nM -
CHEMBL295820 EC50 > 50000.0 nM -
CHEMBL129 ZIDOVUDINE EC50 > 100000.0 nM -
CHEMBL290935 EC50 > 50000.0 nM -
CHEMBL42533 EC50 > 50000.0 nM -