Assay Detail
Functional
CHEMBL652469
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In vitro effective compound concentration required to protect against MSV-induced transformation of C3H/3T3 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | C3H/3T3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.97 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128665 | — | — | 1 | 5.66 |
| CHEMBL128051 | — | — | 1 | 5.25 |
| CHEMBL131285 | — | — | 1 | 5.13 |
| CHEMBL338675 | — | — | 1 | 5.03 |
| CHEMBL128857 | — | — | 1 | 5.00 |
| CHEMBL129313 | — | — | 1 | 4.89 |
| CHEMBL128361 | — | — | 1 | 4.82 |
| CHEMBL339915 | — | — | 1 | 4.80 |
| CHEMBL340928 | — | — | 1 | 4.58 |
| CHEMBL341137 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128665 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL128051 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL131285 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL338675 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL128857 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL129313 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL128361 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL339915 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL340928 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL341137 | — | EC50 | = | 30000.0 | nM | 4.52 |