Assay Detail
Functional
CHEMBL652491
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Compound was tested for its antitumor activity against human lymphoblastic leukemic cells(CCRF-CEM) in vitro
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.72 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34412 | LOMETREXOL | 2.0 | 3 | 8.30 |
| CHEMBL39750 | — | — | 2 | 8.22 |
| CHEMBL40385 | — | — | 2 | 8.22 |
| CHEMBL37936 | — | — | 1 | 7.40 |
| CHEMBL38313 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34412 | LOMETREXOL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL40385 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL39750 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL34412 | LOMETREXOL | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL39750 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL34412 | LOMETREXOL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL37936 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL40385 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL38313 | — | IC50 | = | 600.0 | nM | 6.22 |