Assay Detail
Binding
CHEMBL652502
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Tested for binding affinity against cloned human beta-1 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.17 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12686 | — | — | 1 | 6.85 |
| CHEMBL12718 | — | — | 1 | 6.82 |
| CHEMBL12769 | — | — | 1 | 6.30 |
| CHEMBL12813 | — | — | 1 | 6.00 |
| CHEMBL12450 | — | — | 1 | 6.00 |
| CHEMBL13278 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12686 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL12718 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL12769 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL12813 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL12450 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL13278 | — | IC50 | = | 9000.0 | nM | 5.05 |