Assay Detail
Binding
CHEMBL652553
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Specific binding of [3H]Ro-151788 to GABA-A Benzodiazepine receptor in rat cortex
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies at the benzodiazepine receptor (BZR): a comparison of the substitutent effects of pyrazoloquinolinone analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.34 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144615 | — | — | 1 | 9.62 |
| CHEMBL3144841 | — | — | 1 | 9.42 |
| CHEMBL3144609 | — | — | 1 | 9.24 |
| CHEMBL3144617 | — | — | 1 | 8.68 |
| CHEMBL3144744 | — | — | 1 | 8.41 |
| CHEMBL3144608 | — | — | 1 | 8.40 |
| CHEMBL3144743 | — | — | 1 | 8.10 |
| CHEMBL3144738 | — | — | 1 | 7.16 |
| CHEMBL3144611 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144615 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3144841 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL3144609 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL3144617 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3144744 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3144608 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3144743 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3144738 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3144611 | — | IC50 | = | 990.0 | nM | 6.00 |