Assay Detail
Binding
CHEMBL652557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for inhibition of [3H]diazepam towards Benzodiazepine receptor from rat
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.34 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.22 |
| CHEMBL13662 | CI-218872 | — | 1 | 6.94 |
| CHEMBL451 | CHLORDIAZEPOXIDE | 4.0 | 1 | 6.61 |
| CHEMBL157884 | — | — | 1 | 6.55 |
| CHEMBL155571 | — | — | 1 | 6.51 |
| CHEMBL347033 | — | — | 1 | 6.41 |
| CHEMBL155179 | — | — | 1 | 6.29 |
| CHEMBL347801 | — | — | 1 | 6.23 |
| CHEMBL153823 | — | — | 1 | 6.20 |
| CHEMBL155598 | — | — | 1 | 6.20 |
| CHEMBL346817 | — | — | 1 | 6.15 |
| CHEMBL157522 | — | — | 1 | 6.04 |
| CHEMBL155215 | — | — | 1 | 5.92 |
| CHEMBL352028 | — | — | 1 | 5.65 |
| CHEMBL347965 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL13662 | CI-218872 | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL451 | CHLORDIAZEPOXIDE | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL157884 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL155571 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL347033 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL155179 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL347801 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL153823 | — | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL155598 | — | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL346817 | — | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL157522 | — | IC50 | = | 905.0 | nM | 6.04 |
| CHEMBL155215 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL352028 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL347965 | — | IC50 | = | 7450.0 | nM | 5.13 |