Assay Detail
Binding
CHEMBL652585
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Binding affinity against CHO cells transfected with human beta-3 adrenergic receptor in the presence of [125I]iodocyanopindolol
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Beta 3 agonists. Part 1: evolution from inception to BMS-194449.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 6.15 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317621 | — | — | 1 | 7.96 |
| CHEMBL102222 | — | — | 1 | 7.70 |
| CHEMBL102891 | — | — | 1 | 7.48 |
| CHEMBL102928 | — | — | 1 | 7.36 |
| CHEMBL103147 | — | — | 1 | 7.16 |
| CHEMBL102836 | — | — | 1 | 7.09 |
| CHEMBL103131 | — | — | 1 | 7.09 |
| CHEMBL319257 | — | — | 1 | 6.88 |
| CHEMBL320915 | — | — | 1 | 6.80 |
| CHEMBL102759 | — | — | 1 | 6.66 |
| CHEMBL103784 | — | — | 1 | 6.64 |
| CHEMBL322863 | — | — | 1 | 6.52 |
| CHEMBL101591 | — | — | 1 | 6.50 |
| CHEMBL106329 | — | — | 1 | 6.50 |
| CHEMBL102257 | — | — | 1 | 6.44 |
| CHEMBL321987 | — | — | 1 | 6.38 |
| CHEMBL102522 | — | — | 1 | 6.32 |
| CHEMBL103219 | — | — | 1 | 6.32 |
| CHEMBL405622 | — | — | 1 | 6.28 |
| CHEMBL316546 | — | — | 1 | 6.26 |
| CHEMBL102364 | — | — | 1 | 6.24 |
| CHEMBL284782 | — | — | 1 | 6.18 |
| CHEMBL323091 | — | — | 1 | 6.01 |
| CHEMBL105392 | — | — | 1 | 5.96 |
| CHEMBL103743 | — | — | 1 | 5.82 |
| CHEMBL318579 | — | — | 1 | 5.81 |
| CHEMBL105095 | — | — | 1 | 5.80 |
| CHEMBL102471 | — | — | 1 | 5.55 |
| CHEMBL105430 | — | — | 1 | 5.48 |
| CHEMBL102291 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317621 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL102222 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL102891 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL102928 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL103147 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL102836 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL103131 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL319257 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL320915 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL102759 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL103784 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL322863 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL101591 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL106329 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL102257 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL321987 | — | Ki | = | 414.0 | nM | 6.38 |
| CHEMBL102522 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL103219 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL405622 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL316546 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL102364 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL284782 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL323091 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL105392 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL103743 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL318579 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL105095 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL102471 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL105430 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL102291 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL30746 | SOTERENOL | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL317852 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL105603 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL101693 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL105019 | — | Ki | = | 12700.0 | nM | 4.90 |
| CHEMBL319632 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL103096 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL318830 | — | Ki | = | 87000.0 | nM | 4.06 |