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Compound Detail

CHEMBL322863

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CC(=O)Nc1ccc(C(NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c2ccc(NC(C)=O)cc2)cc1

Basic Information

ChEMBL ID CHEMBL322863
Phase Preclinical
Structure Type MOL
InChI Key DJFOJEILFDLBCU-VWLOTQADSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

526.6
MW (Da)
3.09
ALogP
7
HBA
6
HBD
156.9
PSA (Ų)
0.22
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H30N4O6S
MW 526.62
Aromatic Rings 3
Heavy Atoms 37
NP-Likeness -0.75

Activity Summary

Ki 1 meas. best 6.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
Ki 6.52 6.52 300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11714605 10.1016/s0960-894x(01)00628-x Beta-3 adrenergic receptor 2
11714605 10.1016/s0960-894x(01)00628-x Adrenergic receptor beta; ADRB1 & ADRB3 1
11714605 10.1016/s0960-894x(01)00628-x Beta-2 adrenergic receptor and beta-3 adrenergic receptor 1
11714605 10.1016/s0960-894x(01)00628-x Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine