Assay Detail
Binding
CHEMBL652629
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Inhibitory activity against beta-Lactamase enzyme derived from Enterobacter cloacae P99
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.10 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37794 | — | — | 1 | 7.60 |
| CHEMBL287095 | — | — | 1 | 7.35 |
| CHEMBL36689 | — | — | 1 | 6.89 |
| CHEMBL290112 | — | — | 1 | 6.81 |
| CHEMBL35987 | — | — | 1 | 6.44 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 6.03 |
| CHEMBL269308 | — | — | 1 | 5.60 |
| CHEMBL284539 | — | — | 1 | 5.39 |
| CHEMBL268919 | — | — | 1 | 5.11 |
| CHEMBL33895 | — | — | 1 | 5.05 |
| CHEMBL39640 | — | — | 1 | 4.86 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | - |
| CHEMBL36657 | — | — | 1 | - |
| CHEMBL34981 | — | — | 1 | - |
| CHEMBL36888 | — | — | 1 | - |
| CHEMBL290165 | — | — | 1 | - |
| CHEMBL36213 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37794 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL287095 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL36689 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL290112 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL35987 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 943.0 | nM | 6.03 |
| CHEMBL269308 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL284539 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL268919 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL33895 | — | IC50 | = | 8950.0 | nM | 5.05 |
| CHEMBL39640 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | > | 20000.0 | nM | - |
| CHEMBL36657 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL34981 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL36888 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL290165 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL36213 | — | IC50 | > | 20000.0 | nM | - |