Assay Detail
Functional
CHEMBL652648
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Inhibition of cellular growth against human (CCRF-CEM) leukemias (ATCC) deficient in thymidine kinase.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of enzyme inhibitors using iterative protein crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.70 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 7.37 |
| CHEMBL422395 | — | — | 1 | 6.12 |
| CHEMBL299928 | — | — | 1 | 5.89 |
| CHEMBL417222 | — | — | 1 | 5.80 |
| CHEMBL275685 | — | — | 1 | 5.80 |
| CHEMBL56662 | — | — | 1 | 5.66 |
| CHEMBL291548 | — | — | 1 | 5.46 |
| CHEMBL301844 | — | — | 1 | 5.46 |
| CHEMBL301256 | — | — | 1 | 5.41 |
| CHEMBL56992 | — | — | 1 | 5.39 |
| CHEMBL57002 | — | — | 1 | 5.08 |
| CHEMBL353700 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL422395 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL299928 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL417222 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL275685 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL56662 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL291548 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL301844 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL301256 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL56992 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL57002 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL353700 | — | IC50 | = | 11000.0 | nM | 4.96 |