Assay Detail
Functional
CHEMBL652649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human lymphoblastic leukemia (CCRF-CEM) cell growth measured using a modification of the MTT36 colorimetric assay of Mosmann
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.49 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166027 | — | — | 1 | 6.28 |
| CHEMBL320775 | NOLATREXED | 3.0 | 1 | 6.09 |
| CHEMBL349723 | — | — | 1 | 6.06 |
| CHEMBL166369 | — | — | 1 | 6.00 |
| CHEMBL162145 | — | — | 1 | 5.68 |
| CHEMBL423282 | — | — | 1 | 5.68 |
| CHEMBL162613 | — | — | 1 | 5.54 |
| CHEMBL163411 | — | — | 1 | 5.42 |
| CHEMBL350130 | — | — | 1 | 5.38 |
| CHEMBL351606 | — | — | 1 | 5.31 |
| CHEMBL351403 | — | — | 1 | 5.28 |
| CHEMBL163410 | — | — | 1 | 5.07 |
| CHEMBL164624 | — | — | 1 | 4.98 |
| CHEMBL349969 | — | — | 1 | 4.98 |
| CHEMBL164289 | — | — | 1 | 4.58 |
| CHEMBL351839 | — | — | 1 | - |
| CHEMBL351840 | — | — | 1 | - |
| CHEMBL162498 | — | — | 1 | - |
| CHEMBL164569 | — | — | 1 | - |
| CHEMBL165683 | — | — | 1 | - |
| CHEMBL163096 | — | — | 1 | - |
| CHEMBL163535 | — | — | 1 | - |
| CHEMBL351885 | — | — | 1 | - |
| CHEMBL165453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166027 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL320775 | NOLATREXED | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL349723 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL166369 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL162145 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL423282 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL162613 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL163411 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL350130 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL351606 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL351403 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL163410 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL164624 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL349969 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL164289 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL351839 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL351840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL162498 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL164569 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL165683 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL163096 | — | IC50 | > | 26900.0 | nM | - |
| CHEMBL163535 | — | IC50 | > | 4200.0 | nM | - |
| CHEMBL351885 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL165453 | — | IC50 | > | 50000.0 | nM | - |