Assay Detail
Binding
CHEMBL652656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BZR receptor on bovine cerebral cortex by [3H]flunitrazepam displacement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094107) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
Structure-activity relationships of 1,2,4-triazolo[1,5-a] quinoxalines and their 1-deaza analogues imidazo[1,2-a]quinoxalines at the benzodiazepine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.68 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97569 | — | — | 1 | 8.54 |
| CHEMBL98678 | — | — | 1 | 8.27 |
| CHEMBL97372 | — | — | 1 | 8.05 |
| CHEMBL327853 | — | — | 1 | 8.01 |
| CHEMBL317545 | — | — | 1 | 7.88 |
| CHEMBL316824 | — | — | 1 | 7.84 |
| CHEMBL97286 | — | — | 1 | 7.80 |
| CHEMBL95396 | — | — | 1 | 7.80 |
| CHEMBL94830 | — | — | 1 | 7.76 |
| CHEMBL328437 | — | — | 1 | 7.66 |
| CHEMBL317815 | — | — | 1 | 7.53 |
| CHEMBL319058 | — | — | 1 | 7.48 |
| CHEMBL97349 | — | — | 1 | 7.37 |
| CHEMBL99026 | — | — | 1 | 7.25 |
| CHEMBL98509 | — | — | 1 | 7.17 |
| CHEMBL330399 | — | — | 1 | 7.15 |
| CHEMBL99178 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97569 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL98678 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL97372 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL327853 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL317545 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL316824 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL97286 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL95396 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL94830 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL328437 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL317815 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL319058 | — | Ki | = | 32.8 | nM | 7.48 |
| CHEMBL97349 | — | Ki | = | 42.3 | nM | 7.37 |
| CHEMBL99026 | — | Ki | = | 56.4 | nM | 7.25 |
| CHEMBL98509 | — | Ki | = | 67.5 | nM | 7.17 |
| CHEMBL330399 | — | Ki | = | 71.2 | nM | 7.15 |
| CHEMBL99178 | — | Ki | = | 87.8 | nM | 7.06 |