Assay Detail
Binding
CHEMBL652657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]flunitrazepam binding to GABA-A benzodiazepine receptor of bovine cerebral cortical membranes at 10 uM
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094107) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
Publication
Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.17 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | 4.0 | 1 | 9.42 |
| CHEMBL11908 | — | — | 1 | 8.92 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.00 |
| CHEMBL307644 | — | — | 1 | 6.55 |
| CHEMBL71304 | — | — | 1 | 6.00 |
| CHEMBL71424 | — | — | 1 | 5.92 |
| CHEMBL304527 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL11908 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL12 | DIAZEPAM | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL307644 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL71304 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL71424 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL304527 | — | Ki | = | 4200.0 | nM | 5.38 |