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Assay Detail

CHEMBL652716

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]dihydroalprenolol binding to Beta adrenergic receptor from rat cerebral cortical membranes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Subcellular Membrane
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor beta (CHEMBL2095166)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.
Brossi A, Rice KC, Mak CP, Reden J, Jacobson AE, Nimitkitpaisan Y, Skolnick P, Daly J.
J Med Chem (1980) 23 : 648 -652
PubMed 6248642 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 5.80 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL174984 TRETOQUINOL 2.0 1 7.00
CHEMBL155870 1 6.70
CHEMBL348881 1 6.52
CHEMBL19068 1 6.52
CHEMBL347351 1 6.30
CHEMBL160919 TETRAHYDROPAPAVERINE 1 6.00
CHEMBL349584 1 5.89
CHEMBL155707 1 5.40
CHEMBL160579 1 4.52
CHEMBL156383 1 4.52
CHEMBL157948 1 4.40
CHEMBL351585 PAPAVEROLINE 2.0 1 -
CHEMBL422186 1 -
CHEMBL160310 1 -
CHEMBL160143 1 -
CHEMBL291150 1 -
CHEMBL155991 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL174984 TRETOQUINOL Ki = 100.0 nM 7.00
CHEMBL155870 Ki = 200.0 nM 6.70
CHEMBL348881 Ki = 300.0 nM 6.52
CHEMBL19068 Ki = 300.0 nM 6.52
CHEMBL347351 Ki = 500.0 nM 6.30
CHEMBL160919 TETRAHYDROPAPAVERINE Ki = 1000.0 nM 6.00
CHEMBL349584 Ki = 1300.0 nM 5.89
CHEMBL155707 Ki = 4000.0 nM 5.40
CHEMBL160579 Ki = 30000.0 nM 4.52
CHEMBL156383 Ki = 30000.0 nM 4.52
CHEMBL157948 Ki = 40000.0 nM 4.40
CHEMBL351585 PAPAVEROLINE Ki - nM -
CHEMBL422186 Ki - nM -
CHEMBL160310 Ki > 100000.0 nM -
CHEMBL160143 Ki > 100000.0 nM -
CHEMBL291150 Ki - nM -
CHEMBL155991 Ki - nM -