Assay Detail
Binding
CHEMBL652717
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Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of propranolol analogues as serotonergic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.88 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.62 |
| CHEMBL138136 | — | — | 1 | 5.62 |
| CHEMBL139103 | — | — | 1 | 5.35 |
| CHEMBL138907 | — | — | 1 | 5.30 |
| CHEMBL140417 | — | — | 1 | 5.28 |
| CHEMBL169956 | — | — | 1 | 5.08 |
| CHEMBL334465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL138136 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL139103 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL138907 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL140417 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL169956 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL334465 | — | Ki | > | 10000.0 | nM | - |