Assay Detail
Binding
CHEMBL652732
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Inhibitory concentration against specific binding of [3H]diazepam to Benzodiazepine receptor in rat brain
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Benzodiazepine receptor binding activity of 9-(1-phenylethyl)purines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.08 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.22 |
| CHEMBL56243 | — | — | 1 | 7.96 |
| CHEMBL60919 | — | — | 1 | 6.96 |
| CHEMBL56277 | — | — | 1 | 6.80 |
| CHEMBL451 | CHLORDIAZEPOXIDE | 4.0 | 1 | 6.70 |
| CHEMBL299177 | — | — | 1 | 6.42 |
| CHEMBL7474 | — | — | 1 | 6.36 |
| CHEMBL299242 | — | — | 1 | 6.32 |
| CHEMBL299894 | — | — | 1 | 6.28 |
| CHEMBL7344 | — | — | 1 | 6.05 |
| CHEMBL7293 | — | — | 1 | 5.92 |
| CHEMBL57804 | — | — | 1 | 5.92 |
| CHEMBL301889 | — | — | 1 | 5.77 |
| CHEMBL275514 | — | — | 1 | 5.68 |
| CHEMBL291511 | — | — | 1 | 5.66 |
| CHEMBL60971 | — | — | 1 | 5.52 |
| CHEMBL7723 | 9-BENZYL-6-METHYLSULFANYL-9H-PURINE | — | 1 | 5.48 |
| CHEMBL6889 | — | — | 1 | 4.89 |
| CHEMBL293310 | — | — | 1 | 4.72 |
| CHEMBL274148 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL56243 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL60919 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL56277 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL451 | CHLORDIAZEPOXIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL299177 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL7474 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL299242 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL299894 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL7344 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL7293 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL57804 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL301889 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL275514 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL291511 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL60971 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL7723 | 9-BENZYL-6-METHYLSULFANYL-9H-PURINE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL6889 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL293310 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL274148 | — | IC50 | = | 100000.0 | nM | 4.00 |