Assay Detail
Binding
CHEMBL652733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flunitrazepam from GABA-A Benzodiazepine receptor of rat brain membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.31 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144654 | — | — | 1 | 9.54 |
| CHEMBL327229 | — | — | 1 | 9.49 |
| CHEMBL20042 | CGS-9896 | — | 1 | 9.46 |
| CHEMBL3144769 | — | — | 1 | 9.34 |
| CHEMBL3144653 | — | — | 1 | 9.34 |
| CHEMBL3144770 | — | — | 1 | 8.62 |
| CHEMBL3144771 | — | — | 1 | 7.92 |
| CHEMBL3144656 | — | — | 1 | 7.85 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 7.85 |
| CHEMBL3144652 | — | — | 1 | 7.00 |
| CHEMBL3144651 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144654 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL327229 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL20042 | CGS-9896 | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL3144769 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL3144653 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL3144770 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL3144771 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3144656 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL12 | DIAZEPAM | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3144652 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL3144651 | — | Ki | = | 11000.0 | nM | 4.96 |