Assay Detail
Binding
CHEMBL652744
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Ability to inhibit [3H]WB-4101 binding to alpha-1 adrenergic receptor was determined in rat
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.88 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58792 | FLUANISONE | 2.0 | 1 | 9.06 |
| CHEMBL58377 | — | — | 1 | 8.05 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.51 |
| CHEMBL418140 | — | — | 1 | 7.24 |
| CHEMBL62499 | — | — | 1 | 6.60 |
| CHEMBL278044 | — | — | 1 | 5.96 |
| CHEMBL59186 | — | — | 1 | 5.80 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58792 | FLUANISONE | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL58377 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL418140 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL62499 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL278044 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL59186 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 15000.0 | nM | 4.82 |