Assay Detail
Binding
CHEMBL652746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-1 adrenergic receptor binding affinity of the compound, value taken from literature
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.06 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305038 | — | — | 1 | 9.47 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.13 |
| CHEMBL8618 | NAN-190 | — | 1 | 9.10 |
| CHEMBL279841 | — | — | 1 | 7.92 |
| CHEMBL303234 | — | — | 1 | 7.76 |
| CHEMBL419622 | — | — | 1 | 6.59 |
| CHEMBL303925 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305038 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL2 | PRAZOSIN | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL8618 | NAN-190 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL279841 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL303234 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL419622 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL303925 | — | Ki | = | 374.0 | nM | 6.43 |