Assay Detail
Binding
CHEMBL652843
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Inhibitory activity against TEM-1 (class A) beta-lactamase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.24 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6533 | — | — | 1 | 8.22 |
| CHEMBL6469 | — | — | 1 | 7.72 |
| CHEMBL6461 | Ro-481220 | — | 1 | 7.38 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 7.22 |
| CHEMBL6678 | — | — | 1 | 7.19 |
| CHEMBL269471 | — | — | 1 | 7.13 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6533 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL6469 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL6461 | Ro-481220 | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL6678 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL269471 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL403 | SULBACTAM | IC50 | = | 1400.0 | nM | 5.85 |