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Assay Detail

CHEMBL652899

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Binding
In vitro inhibitory potency was tested against botulinum neurotoxin/B (BoNT/B) expressed as Ki
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Clostridium botulinum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Development of potent inhibitors of botulinum neurotoxin type B.
Anne C, Turcaud S, Quancard J, Teffo F, Meudal H, Fournié-Zaluski MC, Roques BP.
J Med Chem (2003) 46 : 4648 -4656
PubMed 14561084 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 4.72 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99951 2 6.10
CHEMBL25915 1 4.96
CHEMBL26376 1 4.68
CHEMBL143232 1 4.66
CHEMBL140958 1 4.56
CHEMBL143692 1 4.22
CHEMBL140783 1 4.19
CHEMBL282364 1 4.01
CHEMBL414393 1 4.00
CHEMBL357138 1 -
CHEMBL143493 1 -
CHEMBL27519 1 -
CHEMBL140149 1 -
CHEMBL283227 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99951 Ki = 800.0 nM 6.10
CHEMBL99951 Ki = 1600.0 nM 5.80
CHEMBL25915 Ki = 11000.0 nM 4.96
CHEMBL26376 Ki = 21000.0 nM 4.68
CHEMBL143232 Ki = 22000.0 nM 4.66
CHEMBL140958 Ki = 27600.0 nM 4.56
CHEMBL143692 Ki = 60000.0 nM 4.22
CHEMBL140783 Ki = 65000.0 nM 4.19
CHEMBL282364 Ki = 97000.0 nM 4.01
CHEMBL414393 Ki = 100000.0 nM 4.00
CHEMBL357138 Ki = 425000.0 nM -
CHEMBL143493 Ki = 160000.0 nM -
CHEMBL27519 Ki > 1000000.0 nM -
CHEMBL140149 Ki = 250000.0 nM -
CHEMBL283227 Ki = 250000.0 nM -