Assay Detail
Functional
CHEMBL652906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cellular growth by the MTT colorimetric assay in CCRF-CEM, human lymphoblasticof T-cell origin
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.65 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349878 | — | — | 1 | 6.70 |
| CHEMBL1744235 | — | — | 1 | 6.66 |
| CHEMBL350841 | — | — | 1 | 6.44 |
| CHEMBL162592 | — | — | 1 | 6.40 |
| CHEMBL9440 | METESIND | 2.0 | 1 | 6.34 |
| CHEMBL9671 | — | — | 1 | 6.21 |
| CHEMBL348858 | — | — | 1 | 6.16 |
| CHEMBL162593 | — | — | 1 | 6.05 |
| CHEMBL161404 | — | — | 1 | 6.05 |
| CHEMBL161750 | — | — | 1 | 5.90 |
| CHEMBL161453 | — | — | 1 | 5.89 |
| CHEMBL275685 | — | — | 1 | 5.80 |
| CHEMBL159017 | — | — | 1 | 5.70 |
| CHEMBL161053 | — | — | 1 | 5.68 |
| CHEMBL161291 | — | — | 1 | 5.62 |
| CHEMBL162646 | — | — | 1 | 5.60 |
| CHEMBL159039 | — | — | 1 | 5.57 |
| CHEMBL162587 | — | — | 1 | 5.55 |
| CHEMBL159050 | — | — | 1 | 5.55 |
| CHEMBL161341 | — | — | 1 | 5.52 |
| CHEMBL161083 | — | — | 1 | 5.51 |
| CHEMBL436435 | — | — | 1 | 5.51 |
| CHEMBL162411 | — | — | 1 | 5.48 |
| CHEMBL301844 | — | — | 1 | 5.46 |
| CHEMBL157865 | — | — | 1 | 5.41 |
| CHEMBL161173 | — | — | 1 | 5.40 |
| CHEMBL161098 | — | — | 1 | 5.32 |
| CHEMBL351495 | — | — | 1 | 5.30 |
| CHEMBL162539 | — | — | 1 | 5.30 |
| CHEMBL350840 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349878 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1744235 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL350841 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL162592 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL9440 | METESIND | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL9671 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL348858 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL162593 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL161404 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL161750 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL161453 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL275685 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL159017 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL161053 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL161291 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL162646 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL159039 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL162587 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL159050 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL161341 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL161083 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL436435 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL162411 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL301844 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL157865 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL161173 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL161098 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL351495 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL162539 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL350840 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL351499 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1788170 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL159155 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL159072 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL349078 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1744234 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL351601 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL422880 | — | IC50 | > | 3330.0 | nM | - |
| CHEMBL161389 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL161325 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL158281 | — | IC50 | > | 4000.0 | nM | - |