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Assay Detail

CHEMBL652907

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for inhibition of cellular growth by the MTT colorimetric assay in CCRF-CEM, human lymphoblasts of T-cell origin
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Intermediate

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase.
Varney MD, Marzoni GP, Palmer CL, Deal JG, Webber S, Welsh KM, Bacquet RJ, Bartlett CA, Morse CA, Booth CL.
J Med Chem (1992) 35 : 663 -676
PubMed 1542093 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.39 5.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9728 1 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9728 IC50 = 4100.0 nM 5.39