Assay Detail
Functional
CHEMBL652909
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Cytotoxicity against human T-cell acute lymphocytic leukemia CCRF-CEM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.77 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341709 | — | — | 1 | 7.24 |
| CHEMBL321473 | — | — | 1 | 6.44 |
| CHEMBL343222 | — | — | 1 | 5.69 |
| CHEMBL336442 | — | — | 1 | 4.75 |
| CHEMBL343088 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341709 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL321473 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL343222 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL336442 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL343088 | — | IC50 | = | 17600.0 | nM | 4.75 |