Assay Detail
Binding
CHEMBL653017
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Inhibition of [125I]-CCK-8 binding to CCK receptors in rat pancreatic tissue
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted benzolactams.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.02 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1907959 | — | — | 1 | 8.52 |
| CHEMBL1907960 | — | — | 1 | 8.38 |
| CHEMBL47186 | — | — | 1 | 8.15 |
| CHEMBL297816 | — | — | 1 | 7.55 |
| CHEMBL47296 | — | — | 1 | 7.46 |
| CHEMBL43769 | — | — | 1 | 7.22 |
| CHEMBL295524 | — | — | 1 | 6.96 |
| CHEMBL294980 | — | — | 1 | 6.89 |
| CHEMBL2093119 | — | — | 1 | 6.70 |
| CHEMBL412881 | — | — | 1 | 6.70 |
| CHEMBL45166 | — | — | 1 | 5.70 |
| CHEMBL295683 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1907959 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1907960 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL47186 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL297816 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL47296 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL43769 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL295524 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL294980 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2093119 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL412881 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL45166 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL295683 | — | IC50 | = | 100000.0 | nM | 4.00 |