Assay Detail
Binding
CHEMBL653040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against central benzodiazepine receptor(CBR).
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.17 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.25 |
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 7.55 |
| CHEMBL135400 | ZOPICLONE | 4.0 | 1 | 7.54 |
| CHEMBL319567 | — | — | 1 | 6.42 |
| CHEMBL338738 | — | — | 1 | 6.07 |
| CHEMBL335049 | — | — | 1 | - |
| CHEMBL335923 | — | — | 1 | - |
| CHEMBL137689 | — | — | 1 | - |
| CHEMBL135408 | — | — | 1 | - |
| CHEMBL334887 | — | — | 1 | - |
| CHEMBL136030 | — | — | 1 | - |
| CHEMBL134590 | — | — | 1 | - |
| CHEMBL335388 | — | — | 1 | - |
| CHEMBL137730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12 | DIAZEPAM | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL54349 | ALPIDEM | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL135400 | ZOPICLONE | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL319567 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL338738 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL335049 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL335923 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL137689 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL135408 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL334887 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL136030 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL134590 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL335388 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL137730 | — | IC50 | > | 1000.0 | nM | - |