Assay Detail
Binding
CHEMBL653041
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Binding affinity against peripheral benzodiazepine receptor( PBR).
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.36 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | — | 1 | 8.74 |
| CHEMBL135870 | — | — | 1 | 8.72 |
| CHEMBL135869 | — | — | 1 | 8.49 |
| CHEMBL137689 | — | — | 1 | 8.41 |
| CHEMBL54349 | ALPIDEM | 4.0 | 1 | 8.15 |
| CHEMBL134590 | — | — | 1 | 7.40 |
| CHEMBL334887 | — | — | 1 | 6.82 |
| CHEMBL136030 | — | — | 1 | 6.54 |
| CHEMBL135408 | — | — | 1 | 5.80 |
| CHEMBL137730 | — | — | 1 | 4.48 |
| CHEMBL335923 | — | — | 1 | - |
| CHEMBL334761 | — | — | 1 | - |
| CHEMBL2111919 | — | — | 1 | - |
| CHEMBL133313 | — | — | 1 | - |
| CHEMBL335388 | — | — | 1 | - |
| CHEMBL338738 | — | — | 1 | - |
| CHEMBL335049 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL135870 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL135869 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL137689 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL54349 | ALPIDEM | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL134590 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL334887 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL136030 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL135408 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL137730 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL335923 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL334761 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2111919 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL133313 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL335388 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL338738 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL335049 | — | IC50 | > | 1000.0 | nM | - |