Assay Detail
Binding
CHEMBL653042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diazepam from GABA-A Benzodiazepine receptor of rat forebrain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.91 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19732 | CGS-8216 | — | 1 | 9.52 |
| CHEMBL13280 | FLUNITRAZEPAM | 4.0 | 1 | 8.82 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19732 | CGS-8216 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL13280 | FLUNITRAZEPAM | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL12 | DIAZEPAM | IC50 | = | 4.0 | nM | 8.40 |