Assay Detail
Binding
CHEMBL653051
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity at benzodiazepine receptor of rat cerebral cortical membranes by [3H]diazepam displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.21 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69719 | — | — | 1 | 8.55 |
| CHEMBL11709 | — | — | 1 | 8.30 |
| CHEMBL453066 | BETA-CCM | — | 1 | 8.30 |
| CHEMBL307783 | — | — | 1 | 8.00 |
| CHEMBL52750 | — | — | 1 | 7.96 |
| CHEMBL299250 | — | — | 1 | 7.62 |
| CHEMBL1269093 | — | — | 1 | 7.03 |
| CHEMBL66902 | — | — | 1 | 7.01 |
| CHEMBL128348 | — | — | 1 | 6.98 |
| CHEMBL54228 | — | — | 1 | 6.91 |
| CHEMBL129742 | — | — | 1 | 6.45 |
| CHEMBL86231 | — | — | 1 | 6.33 |
| CHEMBL67421 | — | — | 1 | 6.30 |
| CHEMBL87641 | — | — | 1 | 6.27 |
| CHEMBL67951 | — | — | 1 | 6.12 |
| CHEMBL56459 | — | — | 1 | - |
| CHEMBL87331 | — | — | 1 | - |
| CHEMBL54381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69719 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL11709 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL453066 | BETA-CCM | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL307783 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL52750 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL299250 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1269093 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL66902 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL128348 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL54228 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL129742 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL86231 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL67421 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL87641 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL67951 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL56459 | — | IC50 | > | 1280.0 | nM | - |
| CHEMBL87331 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL54381 | — | IC50 | > | 25000.0 | nM | - |