Assay Detail
Binding
CHEMBL653110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diazepam from rat cerebral cortex benzodiazepine receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.48 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19732 | CGS-8216 | — | 1 | 9.66 |
| CHEMBL3144843 | — | — | 1 | 9.49 |
| CHEMBL317036 | — | — | 1 | 9.22 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.30 |
| CHEMBL95085 | — | — | 1 | 7.66 |
| CHEMBL316782 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19732 | CGS-8216 | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL3144843 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL317036 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL12 | DIAZEPAM | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL95085 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL316782 | — | Ki | = | 270.0 | nM | 6.57 |