Assay Detail
Binding
CHEMBL653117
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The compound was evaluated for the inhibition of [125I]- Angiotensin II (AII) binding to rat mesenteric membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Refinement of a molecular model of angiotensin II (AII) employed in the discovery of potent nonpeptide antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.88 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368086 | — | — | 1 | 9.00 |
| CHEMBL173158 | — | — | 1 | 6.36 |
| CHEMBL353234 | — | — | 1 | 5.58 |
| CHEMBL126500 | — | — | 1 | 5.05 |
| CHEMBL39345 | — | — | 1 | 4.92 |
| CHEMBL25528 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368086 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL173158 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL353234 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL126500 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL39345 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL25528 | — | IC50 | = | 43000.0 | nM | 4.37 |