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Assay Detail

CHEMBL653121

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to displace [3H]AII (2 nM) from its specific binding sites in rat adrenal cortical microsome preparation
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094112)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives.
Carini DJ, Duncia JV, Johnson AL, Chiu AT, Price WA, Wong PC, Timmermans PB.
J Med Chem (1990) 33 : 1330 -1336
PubMed 2329554 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.04 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL262958 1 6.85
CHEMBL281939 1 6.82
CHEMBL285127 1 6.80
CHEMBL28227 1 6.57
CHEMBL25956 1 6.51
CHEMBL286054 1 6.47
CHEMBL27589 1 6.40
CHEMBL28441 1 6.40
CHEMBL280530 1 6.31
CHEMBL27216 1 6.04
CHEMBL26321 1 5.96
CHEMBL26839 1 5.92
CHEMBL282978 1 5.85
CHEMBL416929 1 5.75
CHEMBL285353 1 5.62
CHEMBL27059 1 5.60
CHEMBL27280 1 5.54
CHEMBL283445 1 5.27
CHEMBL27770 1 5.23
CHEMBL26838 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL262958 IC50 = 140.0 nM 6.85
CHEMBL281939 IC50 = 150.0 nM 6.82
CHEMBL285127 IC50 = 160.0 nM 6.80
CHEMBL28227 IC50 = 270.0 nM 6.57
CHEMBL25956 IC50 = 310.0 nM 6.51
CHEMBL286054 IC50 = 340.0 nM 6.47
CHEMBL27589 IC50 = 400.0 nM 6.40
CHEMBL28441 IC50 = 400.0 nM 6.40
CHEMBL280530 IC50 = 490.0 nM 6.31
CHEMBL27216 IC50 = 920.0 nM 6.04
CHEMBL26321 IC50 = 1100.0 nM 5.96
CHEMBL26839 IC50 = 1200.0 nM 5.92
CHEMBL282978 IC50 = 1400.0 nM 5.85
CHEMBL416929 IC50 = 1800.0 nM 5.75
CHEMBL285353 IC50 = 2400.0 nM 5.62
CHEMBL27059 IC50 = 2500.0 nM 5.60
CHEMBL27280 IC50 = 2900.0 nM 5.54
CHEMBL283445 IC50 = 5400.0 nM 5.27
CHEMBL27770 IC50 = 5900.0 nM 5.23
CHEMBL26838 IC50 = 12000.0 nM 4.92