Compound Detail
CHEMBL27589
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Basic Information
| ChEMBL ID | CHEMBL27589 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CZVZCKMERXSFKG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
414.9
MW (Da)
4.91
ALogP
5
HBA
2
HBD
84.6
PSA (Ų)
0.52
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor CHEMBL2094112 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Angiotensin II receptor CHEMBL2094256 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin II receptor | IC50 | = | 400.0 | nM | 6.4 | Ability to displace [3H]AII (2 nM) from its specific binding sites in rat adrena... | 2329554 |
| Angiotensin II receptor | IC50 | = | 400.0 | nM | 6.4 | Compound was evaluated for 50% inhibitory concentration against angiotensin II r... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2329554 | 10.1021/jm00167a008 | Angiotensin II receptor | 1 |
| - | 10.1016/S0960-894X(01)81137-9 | Angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine