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Assay Detail

CHEMBL652610

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for 50% inhibitory concentration against angiotensin II receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094256)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists
Poss MA, Gu Z, Ryono DE, Reid JA, Sieber-McMaster E, Spitzmiller ER, Dejneka T, Dickinson KE, Williams SB, Moreland S, Delaney CL, Bird J, Waldron TL, Schaeffer TR, Hedberg S, Petrillo EW
Bioorg Med Chem Lett (1994) 4 : 145 -150
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.53 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL274447 1 6.64
CHEMBL290453 1 6.55
CHEMBL27589 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL274447 IC50 = 230.0 nM 6.64
CHEMBL290453 IC50 = 280.0 nM 6.55
CHEMBL27589 IC50 = 400.0 nM 6.40