Assay Detail
Binding
CHEMBL653122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Angiotensin II receptor antagonist activity was determined by 50% inhibition of specific binding of [3H]angiotensin II (2 nM) to rat adrenal cortical microsomes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.49 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170944 | — | — | 1 | 8.92 |
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 8.70 |
| CHEMBL171524 | — | — | 1 | 8.19 |
| CHEMBL170208 | — | — | 1 | 7.89 |
| CHEMBL995 | LOSARTAN POTASSIUM | 4.0 | 1 | 7.72 |
| CHEMBL170281 | — | — | 1 | 7.32 |
| CHEMBL173654 | — | — | 1 | 7.13 |
| CHEMBL172765 | — | — | 1 | 6.89 |
| CHEMBL352593 | — | — | 1 | 6.54 |
| CHEMBL171136 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170944 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL408403 | ANGIOTENSIN II | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL171524 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL170208 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL170281 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL173654 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL172765 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL352593 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL171136 | — | IC50 | = | 2500.0 | nM | 5.60 |