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Assay Detail

CHEMBL653167

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant carbonic anhydrase I (CA1)
ChEMBL ↗
151
Total Activities
151
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 1 (CHEMBL261) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT.
J Med Chem (2000) 43 : 4542 -4551
PubMed 11087579 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 151 5.97 7.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL342026 — — 1 7.77
CHEMBL141624 — — 1 7.75
CHEMBL140481 — — 1 7.72
CHEMBL138603 — — 1 7.68
CHEMBL139946 — — 1 7.62
CHEMBL140805 — — 1 7.62
CHEMBL142132 — — 1 7.60
CHEMBL18 ETHOXZOLAMIDE 4.0 1 7.60
CHEMBL264879 — — 1 7.55
CHEMBL141899 — — 1 7.54
CHEMBL337328 — — 1 7.43
CHEMBL140110 — — 1 7.39
CHEMBL141168 — — 1 7.35
CHEMBL140792 — — 1 7.31
CHEMBL140370 — — 1 7.30
CHEMBL141753 — — 1 7.27
CHEMBL344156 — — 1 7.26
CHEMBL140616 — — 1 7.19
CHEMBL141351 — — 1 7.16
CHEMBL140095 — — 1 6.98
CHEMBL343916 — — 1 6.92
CHEMBL344001 — — 1 6.90
CHEMBL422825 — — 1 6.82
CHEMBL138920 — — 1 6.70
CHEMBL94836 — — 1 6.68
CHEMBL138253 — — 1 6.60
CHEMBL341760 — — 1 6.60
CHEMBL69149 — — 1 6.57
CHEMBL139763 — — 1 6.54
CHEMBL141868 — — 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL342026 — Ki = 17.0 nM 7.77
CHEMBL141624 — Ki = 18.0 nM 7.75
CHEMBL140481 — Ki = 19.0 nM 7.72
CHEMBL138603 — Ki = 21.0 nM 7.68
CHEMBL140805 — Ki = 24.0 nM 7.62
CHEMBL139946 — Ki = 24.0 nM 7.62
CHEMBL18 ETHOXZOLAMIDE Ki = 25.0 nM 7.60
CHEMBL142132 — Ki = 25.0 nM 7.60
CHEMBL264879 — Ki = 28.0 nM 7.55
CHEMBL141899 — Ki = 29.0 nM 7.54
CHEMBL337328 — Ki = 37.0 nM 7.43
CHEMBL140110 — Ki = 41.0 nM 7.39
CHEMBL141168 — Ki = 45.0 nM 7.35
CHEMBL140792 — Ki = 49.0 nM 7.31
CHEMBL140370 — Ki = 50.0 nM 7.30
CHEMBL141753 — Ki = 54.0 nM 7.27
CHEMBL344156 — Ki = 55.0 nM 7.26
CHEMBL140616 — Ki = 65.0 nM 7.19
CHEMBL141351 — Ki = 70.0 nM 7.16
CHEMBL140095 — Ki = 105.0 nM 6.98
CHEMBL343916 — Ki = 120.0 nM 6.92
CHEMBL344001 — Ki = 125.0 nM 6.90
CHEMBL422825 — Ki = 150.0 nM 6.82
CHEMBL138920 — Ki = 200.0 nM 6.70
CHEMBL94836 — Ki = 210.0 nM 6.68
CHEMBL138253 — Ki = 250.0 nM 6.60
CHEMBL341760 — Ki = 250.0 nM 6.60
CHEMBL69149 — Ki = 270.0 nM 6.57
CHEMBL139763 — Ki = 290.0 nM 6.54
CHEMBL141868 — Ki = 300.0 nM 6.52
CHEMBL139939 — Ki = 300.0 nM 6.52
CHEMBL344382 — Ki = 300.0 nM 6.52
CHEMBL342610 — Ki = 300.0 nM 6.52
CHEMBL138812 — Ki = 300.0 nM 6.52
CHEMBL343098 — Ki = 300.0 nM 6.52
CHEMBL140692 — Ki = 300.0 nM 6.52
CHEMBL343944 — Ki = 325.0 nM 6.49
CHEMBL141425 — Ki = 330.0 nM 6.48
CHEMBL140879 — Ki = 350.0 nM 6.46
CHEMBL337369 — Ki = 360.0 nM 6.44
CHEMBL141898 — Ki = 380.0 nM 6.42
CHEMBL140791 — Ki = 400.0 nM 6.40
CHEMBL342407 — Ki = 400.0 nM 6.40
CHEMBL140252 — Ki = 550.0 nM 6.26
CHEMBL343048 — Ki = 600.0 nM 6.22
CHEMBL140428 — Ki = 710.0 nM 6.15
CHEMBL436573 — Ki = 760.0 nM 6.12
CHEMBL141255 — Ki = 750.0 nM 6.12
CHEMBL96361 — Ki = 760.0 nM 6.12
CHEMBL19 METHAZOLAMIDE Ki = 780.0 nM 6.11