Assay Detail
Binding
CHEMBL653170
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Inhibition of human carbonic anhydrase I (CAI)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 5.90 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13630 | — | — | 1 | 9.00 |
| CHEMBL275565 | — | — | 1 | 8.70 |
| CHEMBL13614 | — | — | 1 | 8.30 |
| CHEMBL268439 | — | — | 1 | 8.22 |
| CHEMBL417986 | — | — | 1 | 7.52 |
| CHEMBL13555 | — | — | 1 | 7.51 |
| CHEMBL269122 | — | — | 1 | 7.38 |
| CHEMBL14182 | — | — | 1 | 7.36 |
| CHEMBL13802 | — | — | 1 | 6.98 |
| CHEMBL276869 | — | — | 1 | 6.70 |
| CHEMBL274895 | — | — | 1 | 6.62 |
| CHEMBL13975 | — | — | 1 | 6.44 |
| CHEMBL13646 | — | — | 1 | 6.34 |
| CHEMBL275091 | — | — | 1 | 6.30 |
| CHEMBL13410 | — | — | 1 | 6.25 |
| CHEMBL266157 | — | — | 1 | 6.21 |
| CHEMBL14198 | — | — | 1 | 6.20 |
| CHEMBL13966 | — | — | 1 | 6.12 |
| CHEMBL13981 | — | — | 1 | 6.10 |
| CHEMBL266387 | — | — | 1 | 6.02 |
| CHEMBL418164 | — | — | 1 | 5.62 |
| CHEMBL407995 | — | — | 1 | 5.52 |
| CHEMBL268177 | — | — | 1 | 5.22 |
| CHEMBL269628 | — | — | 1 | 5.21 |
| CHEMBL6724 | — | — | 1 | 5.19 |
| CHEMBL266240 | — | — | 1 | 5.08 |
| CHEMBL6853 | — | — | 1 | 5.08 |
| CHEMBL265674 | — | — | 1 | 5.07 |
| CHEMBL13929 | — | — | 1 | 5.05 |
| CHEMBL6753 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13630 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL275565 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL13614 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL268439 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL417986 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL13555 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL269122 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL14182 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL13802 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL276869 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL274895 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL13975 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL13646 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL275091 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL13410 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL266157 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL14198 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL13966 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL13981 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL266387 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL418164 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL407995 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL268177 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL269628 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL6724 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL266240 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL6853 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL265674 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL13929 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL6753 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL7092 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL14039 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL13982 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL13851 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL7087 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL13541 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL6852 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL419 | MAFENIDE | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL6705 | — | Ki | = | 45400.0 | nM | 4.34 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL7204 | — | Ki | = | 78500.0 | nM | 4.11 |
| CHEMBL418163 | — | Ki | > | 50000.0 | nM | - |