Assay Detail
Functional
CHEMBL653188
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Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.51 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 7.70 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 6.85 |
| CHEMBL269090 | — | — | 3 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL269090 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL269090 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL269090 | — | EC50 | = | 1880.0 | nM | 5.73 |