Assay Detail
Functional
CHEMBL653190
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Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.43 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 7.30 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 2 | 6.77 |
| CHEMBL269090 | — | — | 3 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL269090 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL269090 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL269090 | — | EC50 | = | 3410.0 | nM | 5.47 |