Assay Detail
Functional
CHEMBL653197
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Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control CEM-SS cells (in vitro anti-HIV activity)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.28 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105916 | — | — | 1 | 9.33 |
| CHEMBL110091 | — | — | 1 | 8.74 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.72 |
| CHEMBL107099 | — | — | 1 | 8.72 |
| CHEMBL418833 | — | — | 1 | 8.54 |
| CHEMBL107535 | — | — | 1 | 8.28 |
| CHEMBL320557 | — | — | 1 | 7.89 |
| CHEMBL418812 | — | — | 1 | 7.20 |
| CHEMBL316514 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105916 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL110091 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL107099 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL418833 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL107535 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL320557 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL418812 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL316514 | — | EC50 | = | 85.0 | nM | 7.07 |