Assay Detail
Functional
CHEMBL653209
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Inhibitory concentration against breast MCF-7 cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.25 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147506 | — | — | 1 | 6.16 |
| CHEMBL98669 | — | — | 1 | 5.82 |
| CHEMBL317814 | — | — | 1 | 5.60 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.30 |
| CHEMBL148313 | — | — | 1 | 5.22 |
| CHEMBL149444 | — | — | 1 | 5.22 |
| CHEMBL353629 | — | — | 1 | 5.16 |
| CHEMBL353658 | — | — | 1 | 5.10 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.00 |
| CHEMBL148968 | — | — | 1 | 4.96 |
| CHEMBL346414 | — | — | 1 | 4.94 |
| CHEMBL149172 | — | — | 1 | 4.54 |
| CHEMBL168668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147506 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL98669 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL317814 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL148313 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL149444 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL353629 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL353658 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL148968 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL346414 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL149172 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL168668 | — | IC50 | > | 37000.0 | nM | - |