Assay Detail
Functional
CHEMBL653225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CCRF-CEM (human leukemia) cell growth in vitro.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417222 | — | — | 1 | 5.84 |
| CHEMBL171706 | — | — | 1 | 5.57 |
| CHEMBL172474 | — | — | 1 | 5.47 |
| CHEMBL291548 | — | — | 1 | 5.46 |
| CHEMBL170573 | — | — | 1 | 5.35 |
| CHEMBL162754 | — | — | 1 | 5.35 |
| CHEMBL171180 | — | — | 1 | 4.98 |
| CHEMBL433923 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417222 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL171706 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL172474 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL291548 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL170573 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL162754 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL171180 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL433923 | — | IC50 | = | 48000.0 | nM | 4.32 |