Assay Detail
Functional
CHEMBL653291
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Antiviral activity was measured on HIV-2 in mutant thymidine kinase-deficient CEM/TK- cells
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.21 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31131 | — | — | 1 | 7.10 |
| CHEMBL376065 | — | — | 1 | 7.03 |
| CHEMBL33528 | — | — | 1 | 6.77 |
| CHEMBL223807 | — | — | 1 | 6.75 |
| CHEMBL375767 | — | — | 1 | 6.30 |
| CHEMBL2115337 | — | — | 1 | 6.10 |
| CHEMBL991 | STAVUDINE | 4.0 | 2 | 4.82 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31131 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL376065 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL33528 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL223807 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL375767 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2115337 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL991 | STAVUDINE | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL991 | STAVUDINE | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL129 | ZIDOVUDINE | EC50 | > | 100000.0 | nM | - |