Assay Detail
Functional
CHEMBL653292
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Antiviral activity was measured on HIV-2 in mutant thymidine kinase-deficient CEM/TK- cells for R configuration
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.07 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376065 | — | — | 1 | 7.20 |
| CHEMBL31131 | — | — | 1 | 7.10 |
| CHEMBL33528 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376065 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL31131 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL33528 | — | EC50 | = | 120.0 | nM | 6.92 |